Instrukcja obsługi Zoetis Rimadyl

Zoetis Niesklasyfikowane Rimadyl

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Strona 1/2
(carprofen)
Caplets/Chewable Tablets
For oral use in dogs only
Sterile Injectable Solution 50 mg/mL
For subcutaneous use in dogs only
Non-steroidal, anti-inflammatory drug
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
DESCRIPTION: Rimadyl (carprofen) is a non-steroidal anti-inflamma tory drug (NSAID) of the propionic acid
class that includes ibuprofen, naproxen, and ketoprofen. Carprofen is the nonproprietary designation for a
substi tuted carbazole, 6-chloro- -methyl-9H-carbazole-2-acetic acid. The empirical formula is Cα15H12
ClNO2
and the molecular weight 273.72. The chemical structure of carprofen is shown above. Carprofen is a white,
crystalline compound. It is freely soluble in ethanol, but practically insoluble in water at 25°C.
Rimadyl Injectable is a sterile solution containing carprofen. Each mL of Rimadyl Injectable contains 50.0 mg
carprofen, 30.0 mg arginine, 88.5 mg glycocholic acid, 169.0 mg lecithin, 10.0 mg benzyl alcohol, 6.17 mg sodium
hydroxide, with additional sodium hydroxide and hydrochloric acid as needed to adjust pH, and water for
injection.
CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with
characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.
1
The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the
inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals.
2 The
constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and
renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation.
Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2
provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary
from species to species.3
In an study using canine cell cultures, carprofen demonstrated selective in vitro
inhibition of COX-2 versus COX-1.
4 Clinical relevance of these data has not been shown. Carprofen has also been
shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear
leukocytes (PMN) and human rheumatoid synovial cells, indicating inhibition of acute (PMN system) and
chronic (synovial cell system) inflammatory reactions.
1
Several studies have demonstrated that carprofen has modulatory effects on both humoral and cellular
immune responses.5 –9 Data also indicate that carprofen inhibits the production of osteoclast-activating factor
(OAF), PGE1, and PGE2
by its inhibitory effects on prostaglandin biosynthesis.
1
Based upon comparison with data obtained from intravenous administration, carprofen is rapidly and
nearly completely absorbed (more than 90% bioavailable) when administered orally.10 Peak blood plasma
concentrations are achieved in 1–3 hours after oral administration of 1, 5, and 25 mg/kg to dogs. The mean
terminal half-life of carprofen is approximately 8 hours (range 4.5–9.8 hours) after single oral doses varying
from 1–35 mg/kg of body weight. After a 100 mg single intravenous bolus dose, the mean elimination half-life
was approximately 11.7 hours in the dog. Rimadyl is more than 99% bound to plasma protein and exhibits a very
small volume of distribution.
Comparison of a single 25 mg dose in Beagle dogs after subcutaneous and oral administration demonstrated
that the dorsoscapular subcutaneous administration results in a slower rate of drug input (as reflected by
mean peak observed concentrations) but comparable total drug absorption within a 12 hour dosing interval
(as reflected by area under the curve from hours zero to 12 postdose).
Carprofen is eliminated in the dog primarily by biotransformation in the liver followed by rapid excretion of the
resulting metabolites (the ester glucuronide of carprofen and the ether glucuronides of 2 phenolic metabolites,
7-hydroxy carprofen and 8-hydroxy carprofen) in the feces (70–80%) and urine (10–20%). Some enterohepatic
circulation of the drug is observed.
INDICATIONS: Rimadyl is indicated for the relief of pain and inflammation associated with osteoarthritis and for
the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
CONTRAINDICATIONS: Rimadyl should not be used in dogs exhibiting previous hypersensitivity to carprofen.
WARNINGS: Keep out of reach of children. Not for human use. Consult a physician in cases of accidental
ingestion by humans. Do not use in cats.For use in dogs only.
All dogs should undergo a thorough history and physical examination before initiation of NSAID therapy.
Appropriate laboratory tests to establish hematolo gical and serum biochemical baseline data prior to, and
periodically during, administration of any NSAID should be considered. Owners should be advised to observe
for signs of potential drug toxicity (see Information for Dog Owners, Adverse Reactions, Animal Safety and
Post-Approval Experience).
PRECAUTIONS: As a class, cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal, renal
and hepatic toxicity. Effects may result from decreased prostaglandin production and inhibition of the enzyme
cyclooxygenase which is responsible for the formation of prosta glandins from arachidonic acid.
11–14 When
NSAIDs inhibit prosta glandins that cause inflammation they may also inhibit those prosta glandins which
maintain normal homeostatic function. These anti-prostaglandin effects may result in clinically sig nificant
disease in patients with underlying or pre-existing disease more often than in healthy patients.
12,14 NSAID
therapy could unmask occult disease which has previously been undiagnosed due to the absence of
apparent clinical signs. Patients with underlying renal disease for example, may experience exacerbation or
decompensation of their renal disease while on NSAID therapy.
11–14
The use of parenteral fluids during surgery
should be considered to reduce the potential risk of renal complications when using NSAIDs perioperatively.
Carprofen is an NSAID, and as with others in that class, adverse reactions may occur with its use. The most
frequently reported effects have been gastrointestinal signs. Events involving suspected renal, hematologic,
neurologic, dermatologic, and hepatic effects have also been reported. Patients at greatest risk for renal toxicity
are those that are dehydrated, on concomitant diuretic therapy, or those with renal, cardiovascular, and/or
hepatic dysfunction. Concurrent administration of potentially nephrotoxic drugs should be approached
cautiously, with appropriate monitoring. Concomitant use of Rimadyl with other anti-inflammatory drugs, such
as other NSAIDs or corticosteroids, should be avoided because of the potential increase of adverse reactions,
including gastrointestinal ulcerations and/or perforations. Sensitivity to drug-associated adverse reactions
varies with the individual patient. Dogs that have experienced adverse reactions from one NSAID may
experience adverse reactions from another NSAID. Rimadyl treatment was not associated with renal toxicity
or gastrointestinal ulceration in well-controlled safety studies of up to 10 times the dose in healthy dogs.
As with any parenterally injected product, good hygienic procedures should be used when administering
Rimadyl Injectable.
Rimadyl is not recommended for use in dogs with bleeding disorders (e.g., Von Willebrand’s disease), as safety
has not been established in dogs with these disorders. The safe use of Rimadyl in animals less than
6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been
established. Safety has not been established for IV or IM administration. Studies to determine the activity
of Rimadyl when administered concomitantly with other protein-bound or similarly metabolized drugs have
not been conducted. Drug compatibility should be monitored closely in patients requiring additional therapy.
Such drugs commonly used include cardiac, anticonvulsant and behavioral medications. It has been
suggested that treatment with carprofen may reduce the level of inhalant anesthetics needed.
15 It is
suggested to use different sites for additional injections. If additional pain medication is warranted after
administration of the total daily dose of Rimadyl, alternative analgesia should be considered. The use of
another NSAID is not recommended. Consider appropriate washout times when switching from one NSAID
to another or when switching from corticosteroids use to NSAID use.
Due to the palatable nature of Rimadyl chewable tablets, store out of reach of dogs in a secured location. Severe
adverse reactions may occur if large quantities of tablets are ingested. If you suspect your dog has consumed
Rimadyl chewable tablets above the labeled dose, please call your veterinarian for immediate assistance and
notify Zoetis at 1-888-963-8471.
INFORMATION FOR DOG OWNERS:
Rimadyl, like other drugs of its class, is not free from adverse reactions. Owners should be advised of the
potential for adverse reactions and be informed of the clinical signs associated with drug intolerance.
Adverse reactions may include decreased appetite, vomiting, diarrhea, dark or tarry stools, increased
water consumption, increased urination, pale gums due to anemia, yellowing of gums, skin or white of
the eye due to jaundice, lethargy, incoordination, seizure, or behavioral changes.
Serious adverse reactions associated with this drug class can occur without warning and in rare situations
result in death (see Adverse Reactions). Owners should be advised to discontinue Rimadyl therapy and
contact their veterinarian immediately if signs of intolerance are observed.
The vast majority of patients with drug related adverse reactions have recovered when the signs are
recognized, the drug is withdrawn, and veterinary care, if appropriate, is initiated. Owners should be
advised of the importance of periodic follow up for all dogs during administration of any NSAID.
ADVERSE REACTIONS: During investigational studies for the caplet formulation with twice daily administration of
1 mg/lb, no clinically significant adverse reactions were reported. Some clinical signs were observed during
field studies (n=297) which were similar for carprofen caplet- and placebo-treated dogs. Incidences of the
following were observed in both groups: vomiting (4%), diarrhea (4%), changes in appetite (3%), lethargy (1.4%),
behavioral changes (1%), and constipation (0.3%). The product vehicle served as control.
There were no serious adverse events reported during clinical field studies with once daily administration
of 2 mg/lb. The following categories of abnormal health observations were reported. The product vehicle
served as control.
Percentage of Dogs with Abnormal Health Observations Reported in Clinical Field Study (2 mg/lb once daily)
Observation Rimadyl (n=129) Placebo (n=132)
Inappetence 1.6 1.5
Vomiting 3.1 3.8
Diarrhea/Soft stool 3.1 4.5
Behavior change 0.8 0.8
Dermatitis 0.8 0.8
PU/PD 0.8 —
SAP increase 7.8 8.3
ALT increase 5.4 4.5
AST increase 2.3 0.8
BUN increase 3.1 1.5
Bilirubinuria 16.3 12.1
Ketonuria 14.7 9.1
Clinical pathology parameters listed represent reports of increases from pre-treatment values; medical
judgment is necessary to determine clinical relevance.
During investigational studies of surgical pain for the caplet formulation, no clinically significant adverse
reactions were reported. The product vehicle served as control.
Percentage of Dogs with Abnormal Health Observations Reported in Surgical Pain Field Studies
with Caplets (2 mg/lb once daily)
Observation* Rimadyl (n=148) Placebo (n=149)
Vomiting 10.1 13.4
Diarrhea/Soft stool 6.1 6.0
Ocular disease 2.7 0
Inappetence 1.4 0
Dermatitis/Skin lesion 2.0 1.3
Dysrhythmia 0.7 0
Apnea 1.4 0
Oral/Periodontal disease 1.4 0
Pyrexia 0.7 1.3
Urinary tract disease 1.4 1.3
Wound drainage 1.4 0
* A single dog may have experienced more than one occurrence of an event.
During investigational studies for the chewable tablet formulation, gastrointestinal signs were observed in
some dogs. These signs included vomiting and soft stools.
There were no serious adverse events reported during clinical field studies for the injectable formulation. The
following categories of abnormal health observations were reported. Saline served as control.
Percentage of Dogs with Abnormal Health Observations Reported in Clinical Field Study with the Injectable
Observation* Rimadyl (n=168) Placebo (n=163)
Vomiting 10.1 9.2
Diarrhea/soft stool 2.4 3.7
Dermatitis 0.6 1.2
Dysrhythmia 0.6 0.6
Swelling 0 1.2
Dehiscence 1.2 0
WBC increase 13.7 6.7
* A single dog may have experienced more than one occurrence of an event.
Post-Approval Experience:
Although not all adverse reactions are reported, the following adverse reactions are based on voluntary
post-approval adverse drug experience reporting. The categories of adverse reactions are listed in decreas ing
order of frequency by body system.
Gastrointestinal: Vomiting, diarrhea, constipation, inappetence, melena, hematemesis, gastrointestinal
ulceration, gastrointestinal bleeding, pancreatitis.
Hepatic: Inappetence, vomiting, jaundice, acute hepatic toxicity, hepatic enzyme elevation, abnormal liver function
test(s), hyperbilirubinemia, bilirubinuria, hypoalbuminemia. Approximately one-fourth of hepatic reports were in
Labrador Retrievers.
Neurologic: Ataxia, paresis, paralysis, seizures, vestibular signs, disorientation.
Urinary: Hematuria, polyuria, polydipsia, urinary incontinence, urinary tract infection, azotemia, acute renal
failure, tubular abnormalities including acute tubular necrosis, renal tubular acidosis, glucosuria.
Behavioral: Sedation, lethargy, hyperactivity, restlessness, aggressiveness.
Hematologic: Immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, blood loss anemia,
epistaxis.
Dermatologic: Pruritus, increased shedding, alopecia, pyotraumatic moist dermatitis (hot spots), necrotizing
panniculitis/vasculitis, ventral ecchymosis.
In rare situations, injection site reactions including necrosis, abscess and seroma formation, and granulomas
have been reported with the injectable formulation.
Immunologic or hypersensitivity: Facial swelling, hives, erythema.
In rare situations, death has been associated with some of the adverse reactions listed above.
To report a suspected adverse reaction call 1-888-963-8471.
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DOSAGE AND ADMINISTRATION: Always provide Client Information Sheet with prescription. Carefully
consider the potential benefits and risk of Rimadyl and other treatment options before deciding to use Rimadyl.
Use the lowest effective dose for the shortest duration consistent with individual response. The recommended
dosage for oral administration to dogs is 2 mg/lb (4.4 mg/kg) of body weight daily. The total daily dose may be
administered as 2 mg/lb of body weight once daily or divided and administered as 1 mg/lb (2.2 mg/kg) twice daily.
For the control of postoperative pain, administer approximately 2 hours before the procedure. Rimadyl caplets
and tablets are scored and dosage should be calculated in half-tablet increments. Tablets can be halved by
placing the tablet on a hard surface and pressing down on both sides of the score. Rimadyl chewable tablets
are palatable and willingly consumed by most dogs when offered by the owner. Therefore, they may be fed by
hand or placed on food. Care should be taken to ensure that the dog consumes the complete dose.
The recommended dosage for subcutaneous administration to dogs is 2 mg/lb (4.4 mg/kg) of body weight
daily. The total daily dose may be administered as either 2 mg/lb of body weight once daily or divided and
administered as 1 mg/lb (2.2 mg/kg) twice daily. For control of post-operative pain, administer approximately
2 hours before the procedure.
PALATABILITY: A controlled palatability study was conducted which demonstrated that Rimadyl chewable
tablets were readily accepted and consumed on first offering by a majority of dogs.
EFFECTIVENESS: Confirmation of the effectiveness of Rimadyl for the relief of pain and inflammation
associated with osteoarthritis, and for the control of postoperative pain associated with soft tissue and
orthopedic surgeries, was demonstrated in placebo-controlled, masked studies examining the
anti-inflammatory and analgesic effectiveness of Rimadyl chewable tablets, caplets and injectable
in various breeds of dogs.
Separate placebo-controlled, masked, multicenter field studies confirmed the anti-inflammatory and
analgesic effectiveness of Rimadyl caplets when dosed at 2 mg/lb once daily or when divided and
administered at 1 mg/lb twice daily. In these two field studies, dogs diagnosed with osteoarthritis showed
statistically significant overall improvement based on lameness evaluations by the veterinarian and owner
observations when administered Rimadyl at labeled doses.
Based upon the blood level comparison between subcutaneous and oral administration, Rimadyl effectiveness for
osteoarthritis after dorsoscapular subcutaneous and oral administration should be similar, although there may
be a slight delay in the onset of relief after subcutaneous injection.
Separate placebo-controlled, masked, multicenter field studies confirmed the effectiveness of Rimadyl caplets
and injectable for the control of postoperative pain when dosed at 2 mg/lb once daily in various breeds of
dogs. In these studies, dogs presented for ovariohysterectomy, cruciate repair and aural surgeries were
administered Rimadyl preoperatively and for a maximum of 3 days (soft tissue) or 4 days (orthopedic)
postoperatively. In general, dogs administered Rimadyl showed statistically significant reduction in
pain scores compared to controls.
ANIMAL SAFETY: Laboratory studies in unanesthetized dogs and clinical field studies have demonstrated
that Rimadyl is well tolerated in dogs after oral administration.
In target animal safety studies, Rimadyl was administered orally to healthy Beagle dogs at 1, 3, and 5 mg/lb
twice daily (1, 3 and 5 times the recommended total daily dose) for 42 consecutive days with no significant
adverse reactions. Serum albumin for a single female dog receiving 5 mg/lb twice daily decreased to 2.1 g/dL
after 2 weeks of treatment, returned to the pre-treatment value (2.6 g/dL) after 4 weeks of treatment, and was
2.3 g/dL at the final 6-week evaluation. Over the 6-week treatment period, black or bloody stools were observed
in 1 dog (1 incident) treated with 1 mg/lb twice daily and in 1 dog (2 incidents) treated with 3 mg/lb twice daily.
Redness of the colonic mucosa was observed in 1 male that received 3 mg/lb twice daily.
Two of 8 dogs receiving 10 mg/lb orally twice daily (10 times the recommended total daily dose) for 14 days
exhibited hypoalbuminemia. The mean albumin level in the dogs receiving this dose was lower (2.38 g/dL) than
each of 2 placebo control groups (2.88 and 2.93 g/dL, respectively). Three incidents of black or bloody stool
were observed in 1 dog. Five of 8 dogs exhibited reddened areas of duodenal mucosa on gross
pathologic examination. Histologic examination of these areas revealed no evidence of ulceration,
but did show minimal congestion of the lamina propria in 2 of the 5 dogs.
In separate safety studies lasting 13 and 52 weeks, respectively, dogs were administered orally up to
11.4 mg/lb/day (5.7 times the recommended total daily dose of 2 mg/lb) of carprofen. In both studies, the drug
was well tolerated clinically by all of the animals. No gross or histologic changes were seen in any of the
treated animals. In both studies, dogs receiving the highest doses had average increases in serum L-alanine
aminotransferase (ALT) of approximately 20 IU.
In the 52-week study, minor dermatologic changes occurred in dogs in each of the treatment groups but not in
the control dogs. The changes were described as slight redness or rash and were diagnosed as non-specific
dermatitis. The possibility exists that these mild lesions were treatment related, but no dose relationship was
observed.
Clinical field studies were conducted with 549 dogs of different breeds at the recommended oral doses for
14 days (297 dogs were included in a study evaluating 1 mg/lb twice daily and 252 dogs were included in a
separate study evaluating 2 mg/lb once daily). In both studies the drug was clinically well tolerated and the
incidence of clinical adverse reactions for Rimadyl-treated animals was no higher than placebo-treated
animals (placebo contained inactive ingredients found in Rimadyl). For animals receiving 1 mg/lb twice daily,
the mean post-treatment serum ALT values were 11 IU greater and 9 IU less than pre-treatment values for
dogs receiving Rimadyl and placebo, respectively. Differences were not statistically significant. For animals
receiving 2 mg/lb once daily, the mean post-treatment serum ALT values were 4.5 IU greater and 0.9 IU
less than pre-treatment values for dogs receiving Rimadyl and placebo, respectively. In the latter study,
3 Rimadyl-treated dogs developed a 3-fold or greater increase in (ALT) and/or (AST) during the course of
therapy. One placebo-treated dog had a greater than 2-fold increase in ALT. None of these animals showed
clinical signs associated with laboratory value changes. Changes in the clinical laboratory values (hematology
and clinical chemistry) were not considered clinically significant. The 1 mg/lb twice daily course of therapy was
repeated as needed at 2-week intervals in 244 dogs, some for as long as 5 years.
Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue
surgery. Dogs were administered 2 mg/lb of Rimadyl 2 hours prior to surgery then once daily, as needed for
2 days (soft tissue surgery) or 3 days (orthopedic surgery). Rimadyl was well tolerated when used in
conjunction with a variety of anesthetic-related drugs. The type and severity of abnormal health observation in
Rimadyl- and placebo-treated animals were approximately equal and few in number (see Adverse Reactions).
The most frequent abnormal health observation was vomiting and was observed at approximately the same
frequency in Rimadyl- and placebo-treated animals. Changes in clinicopathologic indices of hematopoietic,
renal, hepatic, and clotting function were not clinically significant. The mean post- treatment serum ALT values
were 7.3 IU and 2.5 IU less than pre-treatment values for dogs receiving Rimadyl and placebo, respectively.
The mean post-treatment AST values were 3.1 IU less for dogs receiving Rimadyl and 0.2 IU greater for dogs
receiving placebo.
Clinical field studies on the use of Rimadyl Injectable were conducted on 331 dogs undergoing orthopedic or
soft tissue surgery. Dogs were administered 2 mg/lb of Rimadyl subcutaneously 2 hours prior to surgery and
once daily thereafter, as needed, for 2 days (soft tissue surgery) or 3 days (orthopedic surgery). Rimadyl was
well tolerated when used in conjunction with a variety of anesthetic-related drugs. The type and severity of
abnormal health observations in Rimadyl- and placebo-treated animals were approximately equal and few
in number (see Adverse Reactions). The most frequent abnormal health observation was vomiting and was
observed at approximately the same frequency in Rimadyl- and placebo-treated animals. Changes in clinico-
pathologic indices of hematopoietic, renal, hepatic, and clotting function were not clinically significant. The
mean post-treatment serum ALT values were 8.4 IU and 7.0 IU less than pre-treatment values for dogs
receiving Rimadyl and placebo, respectively. The mean post-treatment AST values were 1.5 IU and 0.7 IU
greater for dogs receiving Rimadyl and placebo, respectively.
Swelling and warmth were associated with the injection site after subcutaneous administration of Rimadyl
Injectable. These findings were not clinically significant. Long term use of the injectable has not been studied.
STORAGE: Store tablets at controlled room temperature 15°–30°C (59°–86°F). Store injectable under
refrigeration 2°–8°C (36°–46°F). Once broached, product may be stored at temperatures up to 25°C (77°F)
for 28 days.
HOW SUPPLIED: Rimadyl caplets and chewable tablets are scored, and contain 25 mg, 75 mg, or 100 mg of
carprofen per caplet or tablet. Each caplet size is packaged in bottles containing 30, 60, or 180 caplets, or
blister packs containing 4 caplets. Each chewable tablet size is packaged in bottles containing 7, 30, 60, or
180 tablets. Rimadyl Injectable is supplied in 20-mL, amber, glass, sterile, multi-dose vials.
REFERENCES:
1. Baruth H, In Vol. II, Newer Anti-Inflammatory Drugs, et al: Anti-Inflammatory and Anti-Rheumatic Drugs,
Rainsford KD, ed. CRC Press, Boca Raton, p. 33-47, 1986.
2. Vane JR, Botting RM: Mechanism of action of anti-inflammatory drugs. 25:102, pp. 9–21.Scand J Rheumatol
3. Grossman CJ, Wiseman J, Lucas FS, Inhibition of constitutive and inducible cyclooxygenase activity et al:
in human platelets and mononuclear cells by NSAIDs and C -2 inhibitors.OX Inflammation Research
44:253–257, 1995.
4. Ricketts AP, Lundy KM, Seibel SB: Evaluation of selective inhibition of canine cyclooxygenase 1 and 2
by carprofen and other nonste roi dal anti-inflammatory drugs. 59:11, pp. 1441–1446, Am J Vet Res
November 1998.
5. Ceuppens JL, et al: Non-steroidal anti-inflammatory agents inhibit the synthesis of IgM rheumatoid factor
in vitro. Lancet 1:528, 1982.
6. Ceuppens JL, et al: Endogenous prostaglandin E2
enhances polyclonal immunoglobulin production by
ionically inhibiting T suppressor cell activity. 70:41, 1982.Cell Immunol
7. Schleimer RP, et al: The effects of prostaglandin synthesis inhibition on the immune response.
Immunopharmacology 3:205, 1981.
8. Leung KH, et al: Modulation of the development of cell mediated immunity: Possible roles of the products of
cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism. Int J Immuno pharma cology
4:195, 1982.
9. Veit BC: Immunoregulatory activity of cultured-induced suppressor macrophages. 72:14, 1982.Cell Immunol
10. Schmitt M, et al: Biopharmaceutical evaluation of carprofen following single intravenous, oral, and rectal
doses in dogs. 11(7):585–94, 1990.Biopharm Drug Dispos
11. Kore AM: Toxicology of nonsteroidal anti-inflammatory drugs. Veter inary Clinics of North America, Small
Animal Practice 20, March 1990.
12. Binns SH: Pathogenesis and pathophysiology of ischemic injury in cases of acute renal failure. Compend
for Cont Ed 16:1, January 1994.
13. Boothe DM: Prostaglandins: Physiology and clinical implications. 6:11, November 1984.Compend for Cont Ed
14. Rubin SI: Nonsteroidal anti-inflammatory drugs, prostaglandins, and the kidney. 188:9, May 1986.JAVMA
15. Ko CH, Lange DN, Mandsager RE, Effects of butorphanol and carprofen on the minimal alveolar et al:
concentration of isoflurane in dogs. 217:1025–1028, 2000.JAVMA
For a copy of the Safety Data Sheet (SDS) call 1-888-963-8471. To report adverse reactions call Zoetis Inc. at
1-888-963-8471.
Approved by FDA under NADA #141-053, NADA #141-111, NADA #141-199
Distributed by:
Zoetis Inc.
Kalamazoo, MI 49007
Based on Rimadyl Caplets PI 40028070, Revised May 2019;
Rimadyl Chewable Tablets PI 40026875, Revised April 2019; and
Rimadyl Sterile Injectable Solution PI 4019448,
Revised March 2019.

Specyfikacje produktu

Marka: Zoetis
Kategoria: Niesklasyfikowane
Model: Rimadyl

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